Altered cortical and subcortical connectivity due to infrasound administered near the hearing threshold – Evidence from fMRI

PLOS One|Markus Weichenberger, Martin Bauer, et.al. |April 12, 2017
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This useful research identified changes in brain activity when an individual is exposed to infrasound that is just below the hearing range. The abstract and conclusion of the paper are provided below. The full paper can be downloaded at the document links on this page.

In the present study, the brain’s response towards near- and supra-threshold infrasound (IS) stimulation (sound frequency < 20 Hz) was investigated under resting-state fMRI conditions. The study involved two consecutive sessions. In the first session, 14 healthy participants underwent a hearing threshold—as well as a categorical loudness scaling measurement in which the individual loudness perception for IS was assessed across different sound pressure levels (SPL). In the second session, these participants underwent three resting-state acquisitions, one without auditory stimulation (no-tone), one with a monaurally presented 12-Hz IS tone (near-threshold) and one with a similar tone above the individual hearing threshold corresponding to a ‘medium loud’ hearing sensation (supra-threshold).
Data analysis mainly focused on local connectivity measures by means of regional homogeneity (ReHo), but also involved independent component analysis (ICA) to investigate interregional connectivity. ReHo analysis revealed significantly higher local connectivity in right superior temporal gyrus (STG) adjacent to primary auditory cortex, in anterior cingulate cortex (ACC) and, when allowing smaller cluster sizes, also in the right amygdala (rAmyg) during the near-threshold, compared to both the supra-threshold and the no-tone condition. Additional independent component analysis (ICA) revealed large-scale changes of functional connectivity, reflected in a stronger activation of the right amygdala (rAmyg) in the opposite contrast (no-tone > near-threshold) as well as the right superior frontal gyrus (rSFG) during the near-threshold condition. In summary, this study is the first to demonstrate that infrasound near the hearing threshold may induce changes of neural activity across several brain regions, some of which are known to be involved in auditory processing, while others are regarded as keyplayers in emotional and autonomic control. These findings thus allow us to speculate on how continuous exposure to (sub-)liminal IS could exert a pathogenic influence on the organism, yet further (especially longitudinal) studies are required in order to  substantialize these findings.
To our knowledge, this study is the first to document changes of brain activity across several regions in response to prolonged near-threshold IS using fMRI. ReHo analysis revealed higher local connectivity of rSTG, ACC and the rAmyg only when IS was administered near the hearing threshold and ICA showed that effects can also be found on the inter-regional level. On the one hand, these results seem to support the hypothesis that (sub-)liminal IS can exert an influence on the organism via a subconscious processing route (which supposedly involves outer hair cell-mediated signal transduction). On the other hand, though clearly audible, prolonged stimulation with IS above the hearing threshold did not lead to changes of brain activity, which could indicate that the signal processed along the conscious hearing route may have been attenuated in a top-down fashion via attentional mechanisms.
Also, since the brain’s response to prolonged near-threshold IS involves the activation of brains areas, which are known to play a crucial role in emotional and autonomic control, a potential link between IS induced changes of brain activity and the emergence of various physiological as well as psychological health effects can be established. Transient upregulation of these brain areas in response to below- or near threshold IS may thus reflect an initial stress response of the body, eventually promoting symptom formation as stimulation occurs repeatedly and additional risk factor come into play. Nevertheless, further research, in particular longitudinal exposure research, is needed in order sustantiate these findings and contribute to a better understand of IS-related health effects.


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